Article
Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5.
Current genetics - 1 May 1992
Meyers S, Schauer W, Balzi E, Wagner M, Goffeau A, Golin J
Abstract excerpt
The network of genes which mediates multiple drug resistance in yeast includes, among others, the PDR1 gene, which encodes a putative regulator of gene expression, and PDR5, a locus whose amplification leads to resistance. We demonstrate that disruption of PDR5 causes marked hypersensitivity not only to cycloheximide but also to sulphometuron methyl and the mitochondrial inhibitors chloramphenicol, lincomycin,...
Topics
- Anti-Bacterial Agents
- Blotting, Northern
- Blotting, Southern
- DNA Transposable Elements
- Drug Resistance, Microbial
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Mutation
- Yeasts