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Immortality of cell lines: challenges and advantages of establishment

24 Jun 2013

Abstract excerpt

Cellular immortality happens upon impairment of cell-cycle checkpoint pathways (p53/p16/pRb), reactivation or up-regulation of telomerase enzyme, or upregulation of some oncogenes or oncoproteins leading to a higher rate of cell division.There are also some other factors and mechanisms involved in immortalisation, which need to be discovered. Immortalisation of cells derived from different sources and...

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PMID: 23723166
DOI: 10.1002/cbin.10137

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