Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels.

doi:10.1126/science.8146663

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Article

Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels.

Science (New York, N.Y.) - 8 Apr 1994

Etcheberrigaray R, Ito E, Kim C S, Alkon D L

Abstract excerpt

Although beta-amyloid is the main constituent of neurite plaques and may play a role in the pathophysiology of Alzheimer's disease, mechanisms by which soluble beta-amyloid might produce early symptoms such as memory loss before diffuse plaque deposition have not been implicated. Treatment of fib...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Bombesin
Calcium
Cell Line
Cells, Cultured
Dimethyl Sulfoxide
Female
Fibroblasts
Humans
Male
Phenotype
Potassium Channel Blockers
Potassium Channels
Potassium Chloride
Solubility
Tetraethylammonium
Tetraethylammonium Compounds

Source

Open in PubMed

Identifiers

PMID: 8146663
DOI: 10.1126/science.8146663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8146663-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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