Article
Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels.
Science (New York, N.Y.) - 8 Apr 1994
Etcheberrigaray R, Ito E, Kim C S, Alkon D L
Abstract excerpt
Although beta-amyloid is the main constituent of neurite plaques and may play a role in the pathophysiology of Alzheimer's disease, mechanisms by which soluble beta-amyloid might produce early symptoms such as memory loss before diffuse plaque deposition have not been implicated. Treatment of fibroblasts with beta-amyloid (10 nM) induced the same potassium channel dysfunction previously shown to occur...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.