Article
Soluble beta-amyloid induces Alzheimer's disease features in human fibroblasts and in neuronal tissues.
Life sciences - 1 Jan 1996
Etcheberrigaray R, Payne J L, Alkon D L
Abstract excerpt
It has been shown that K+ channels, Cp20 (a 20kD GTP-binding protein), and intracellular calcium release, play a key role in associative memory storage. These same elements have been shown to be altered in fibroblasts from Alzheimer's Disease (AD) patients. In addition, it has been shown that PKC, also implicated in memory storage and closely related to the above mentioned components, is also altered in AD...
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