Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases.

The Journal of biological chemistry - 30 Jul 2010

Dulic Morana, Cvetesic Nevena, Perona John J, Gruic-Sovulj Ita

Abstract excerpt

Hydrolytic editing activities are present in aminoacyl-tRNA synthetases possessing reduced amino acid discrimination in the synthetic reactions. Post-transfer hydrolysis of misacylated tRNA in class I editing enzymes occurs in a spatially separate domain inserted into the catalytic Rossmann fold, but the location and mechanisms of pre-transfer hydrolysis of misactivated amino acids have been uncertain. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acyl-tRNA Synthetases
Share to Catalysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Molecular Conformation

Share to Nucleic Acids

Share to RNA Editing

Share to RNA, Transfer

Share to Valine

Source

Open in PubMed Open full text

Identifiers

PMID: 20498377
DOI: 10.1074/jbc.M110.133553
PMCID: PMC2911327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases.PMID 20498377Read ↗

Mutational unmasking of a tRNA-dependent pathway for preventing genetic code ambiguity.Semantic proximity Read ↗

The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation.Semantic proximity Read ↗

tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase.Semantic proximity Read ↗

Mutational isolation of a sieve for editing in a transfer RNA synthetase.Semantic proximity Read ↗

Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability.Semantic proximity Read ↗

An isolated class II aminoacyl-tRNA synthetase insertion domain is functional in amino acid editing.Semantic proximity Read ↗

Defects in transient tRNA translocation bypass tRNA synthetase quality control mechanisms.Semantic proximity Read ↗

A glycine hinge for tRNA-dependent translocation of editing substrates to prevent errors by leucyl-tRNA synthetase.Semantic proximity Read ↗

Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases.Semantic proximity Read ↗

Multiple Quality Control Pathways Limit Non-protein Amino Acid Use by Yeast Cytoplasmic Phenylalanyl-tRNA Synthetase.Semantic proximity Read ↗

Transfer RNA-mediated editing in threonyl-tRNA synthetase. The class II solution to the double discrimination problem.Semantic proximity Read ↗

Transfer RNA determinants for translational editing by Escherichia coli valyl-tRNA synthetase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.