Article
Role for interferon-gamma in rat strains with different susceptibility to experimental autoimmune myasthenia gravis.
Clinical immunology (Orlando, Fla.) - 1 May 2000
Wang H B, Shi F D, Li H, van der Meide P H, Ljunggren H G, Link H
Abstract excerpt
Experimental autoimmune myasthenia gravis (EAMG) is caused by autoantibodies against the nicotinic acetylcholine receptor (AChR) at the neuromuscular postsynaptic membrane and represents an animal model of myasthenia gravis in human. Recent studies highlighted the roles of TH1 cytokines (IFN-gamma, IL-12), rather than TH2 cytokines (IL-4), in the pathogenesis of EAMG by using homozygous (-/-) knockout mice with...
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