Article
Analysis of Helicobacter pylori vacA gene and serum antibodies to VacA in Japan.
Digestive diseases and sciences - 1 Apr 2000
Shirasaka D, Aoyama N, Satonaka K, Shirakawa K, Yoshida H, Sakai T, Ikemura T, Shinoda Y, Sakashita M, Miyamoto M, Yahiro K, Wada A, Kurazono H, Hirayama T, Kasuga M
Abstract excerpt
Vacuolating cytotoxin, VacA, is one of the most important pathogenetic factors produced by Helicobacter pylori. However, it is not clear whether the diversity in disease outcome may be ascribed to variations in strain and/or to the host responses to virulence factors. In this study, we analyzed the vacA middle region sequence among 65 Japanese isolates to clarify the variation in strain and assayed antibody titer...
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