Article
Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori.
The Journal of infectious diseases - 1 Nov 1998
Ito Y, Azuma T, Ito S, Suto H, Miyaji H, Yamazaki Y, Kohli Y, Kuriyama M
Abstract excerpt
Some clinical isolates of Helicobacter pylori fail to express vacuolating cytotoxin, despite possessing a copy of the vacA gene on the chromosome. To gain insight into the differences between vacA from cytotoxic and noncytotoxic strains, the vacA open-reading frames from 16 cytotoxic and 22 noncy...
Topics
- Bacterial Proteins
- Bacterial Toxins
- Base Sequence
- Cytotoxins
- Frameshift Mutation
- Genetic Variation
- Genotype
- Helicobacter pylori
- Humans
- In Vitro Techniques
- Molecular Sequence Data
- Mutation, Missense
- Open Reading Frames
- Phylogeny