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Article

Single amino acid substitutions of alpha 1-antitrypsin that confer enhancement in thermal stability.

The Journal of biological chemistry - 1 Apr 1994

Kwon K S, Kim J, Shin H S, Yu M H

Abstract excerpt

A recombinant alpha 1-antitrypsin variant which increased thermal stability was obtained from random mutagenesis followed by screening. The clone was identified as having a single mutation of Phe51-->Cys. Heat deactivation of purified recombinant alpha 1-antitrypsin produced in Escherichia coli revealed that the mutation slowed down the deactivation rate 10-fold at 57 degrees C, increasing thermal stability of...

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Source

Identifiers

PMID: 8144550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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