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Article

Effect of genetic variation on the thermal stability of human serum albumin.

Biochimica et biophysica acta - 14 Feb 2005

Kragh-Hansen Ulrich, Saito Shiori, Nishi Koji, Anraku Makoto, Otagiri Masaki

Abstract excerpt

Reversible thermal denaturation of 33 genetic variants of human serum albumin (HSA) appeared to be a two-state process when studied by circular dichroism (CD). Fourteen single-residue variants have Tm values (midpoint of denaturation) higher than, and nine have Tm values lower than, their endogenous, wild-type counterpart. Nine single-residue variants have DeltaHv values (van't Hoff enthalpy) higher than, and 14...

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Identifiers

PMID: 15680241
DOI: 10.1016/j.bbapap.2004.09.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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