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Article

Effect of genetic variation on the thermal stability of human serum albumin.

Biochimica et biophysica acta - 14 Feb 2005

Kragh-Hansen Ulrich, Saito Shiori, Nishi Koji, Anraku Makoto, Otagiri Masaki

Abstract excerpt

Reversible thermal denaturation of 33 genetic variants of human serum albumin (HSA) appeared to be a two-state process when studied by circular dichroism (CD). Fourteen single-residue variants have Tm values (midpoint of denaturation) higher than, and nine have Tm values lower than, their endogenous, wild-type counterpart. Nine single-residue variants have DeltaHv values (van't Hoff enthalpy) higher than, and 14...

Topics

Circular Dichroism
Genetic Variation
Humans
Mutation
Protein Denaturation
Protein Structure, Secondary
Serum Albumin
Temperature

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15680241
DOI: 10.1016/j.bbapap.2004.09.025

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