Article
Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis.
American journal of respiratory and critical care medicine - 1 Apr 1994
Robinson D S, Ying S, Taylor I K, Wangoo A, Mitchell D M, Kay A B, Hamid Q, Shaw R J
Abstract excerpt
Mycobacterium-specific human helper T-cell clones produce a Th1 pattern of cytokines in vitro: interferon-gamma (IFN-gamma) and interleukin-2 (IL-2), but little or no IL-4 or IL-5. To test the hypothesis that a similar Th1-like pattern of cytokine gene expression occurs in vivo in pulmonary tuberculosis we used in situ hybridization to detect cytokine mRNA expression by bronchoalveolar lavage cells from nine...
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