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Synergy between Th1 and Th2 responses duringMycobacterium tuberculosisinfection: A review of current understanding

27 Jun 2019

Abstract excerpt

Induction of Th1 (cell-mediated) immunity and associated production of IFN-γ by CD4+ T cells has been widely used as a marker of protective immunity against tuberculosis (TB). This is based on two assumptions. The first is the widely accepted view that Mycobacterium tuberculosis (Mtb), the causative agent of TB is an obligate intracellular pathogen, and the second is based on the Th1/Th2 paradigm, which posits...

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PMID: 31244354
DOI: 10.1080/08830185.2019.1632842

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