Article
Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes.
The European respiratory journal - 1 Mar 2018
Broos Caroline E, Koth Laura L, van Nimwegen Menno, In 't Veen Johannes C C M, Paulissen Sandra M J, van Hamburg Jan Piet, Annema Jouke T, Heller-Baan Roxane, Kleinjan Alex, Hoogsteden Henk C, Wijsenbeek Marlies S, Hendriks Rudi W, van den Blink Bernt, Kool Mirjam
Abstract excerpt
The lung-draining mediastinal lymph nodes (MLNs) are currently widely used to diagnose sarcoidosis. We previously reported that T-helper (Th) 17.1 cells are responsible for the exaggerated interferon-γ production in sarcoidosis lungs. In this study, we aimed to investigate 1) whether Th17.1 cells are also increased in the MLNs of sarcoidosis patients and 2) whether frequencies of the Th17.1 cells at diagnosis may...
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