Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation.

doi:10.1128/JVI.66.6.3669-3676.1992

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Article

Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation.

Journal of virology - 1 Jun 1992

Dinman J D, Wickner R B

Abstract excerpt

About 1.9% of ribosomes translating the gag open reading frame of the yeast L-A double-stranded RNA virus positive strand undergo a -1 frameshift and continue translating in the pol open reading frame to make a 170-kDa gag-pol fusion protein. The importance of frameshifting efficiency for viral propagation was tested in a system where the M1 (killer toxin-encoding) satellite RNA is supported by a full-length L-A...

Topics

Base Sequence
Frameshift Mutation
Fungal Proteins
Fusion Proteins, gag-pol
Gene Products, gag
Host-Parasite Interactions
Killer Factors, Yeast
Models, Genetic
Molecular Sequence Data
Mutation
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteins

RNA Viruses

RNA, Double-Stranded

RNA, Transfer, Amino Acyl

RNA, Viral

Ribosomes

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 1583726
DOI: 10.1128/JVI.66.6.3669-3676.1992
PMCID: PMC241150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1583726-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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