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Article

Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.

Molecular and cellular biology - 1 Jan 1999

Peltz S W, Hammell A B, Cui Y, Yasenchak J, Puljanowski L, Dinman J D

Abstract excerpt

Programmed -1 ribosomal frameshifting is utilized by a number of RNA viruses as a means of ensuring the correct ratio of viral structural to enzymatic proteins available for viral particle assembly. Altering frameshifting efficiencies upsets this ratio, interfering with virus propagation. We have previously demonstrated that compounds that alter the kinetics of the peptidyl-transfer reaction affect programmed -1...

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Identifiers

PMID: 9858562
DOI: 10.1128/MCB.19.1.384
PMCID: PMC83896

Genes

RPL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.PMID 9858562Read ↗

Decreased peptidyltransferase activity correlates with increased programmed -1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Delayed rRNA processing results in significant ribosome biogenesis and functional defects.Semantic proximity Read ↗

rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.Semantic proximity Read ↗

Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit.Semantic proximity Read ↗

Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes.Semantic proximity Read ↗

Ribosomal protein L5 helps anchor peptidyl-tRNA to the P-site in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ribosomal protein L3: influence on ribosome structure and function.Semantic proximity Read ↗

Identification of functionally important amino acids of ribosomal protein L3 by saturation mutagenesis.Semantic proximity Read ↗

Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency.Semantic proximity Read ↗

Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation.Semantic proximity Read ↗

A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae.Semantic proximity Read ↗

A viable amino acid editing activity in the leucyl-tRNA synthetase CP1-splicing domain is not required in the yeast mitochondria.Semantic proximity Read ↗

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