Article
Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.
Molecular and cellular biology - 1 Jan 1999
Peltz S W, Hammell A B, Cui Y, Yasenchak J, Puljanowski L, Dinman J D
Abstract excerpt
Programmed -1 ribosomal frameshifting is utilized by a number of RNA viruses as a means of ensuring the correct ratio of viral structural to enzymatic proteins available for viral particle assembly. Altering frameshifting efficiencies upsets this ratio, interfering with virus propagation. We have...
Topics
- Alleles
- Exoribonucleases
- Exosome Multienzyme Ribonuclease Complex
- Frameshift Mutation
- Gene Expression
- Mutation
- Peptidyl Transferases
- Plasmids
- RNA Viruses
- Ribosomal Protein L3
- Ribosomal Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription, Genetic