Article
Sheep haemoglobin I or beta B13(A10)Gly-->Ser: an example of a CpG mutation in vertebrates. Characterization using FAB-mass spectrometry and amino acid sequencing.
The International journal of biochemistry - 1 Dec 1993
Manca L, Ferranti P, Barone F, Nitti G, Malorni A, Pucci P, Naitana S, Masala B
Abstract excerpt
1. The amino acid substitution which characterizes the haemoglobin I variant from sheep has been ascertained using a combination of Fast Atom Bombardment mass spectrometry and protein sequencing. 2. A Ser for Gly substitution at position 13 (10 of the A helix) was found in a polypeptide with the overall sequence of the beta B globin. 3. On the basis of the nucleotide sequence of the beta B-globin gene, a C to T...
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