Article
Sheep haemoglobin I or beta B13(A10)Gly-->Ser: an example of a CpG mutation in vertebrates. Characterization using FAB-mass spectrometry and amino acid sequencing.
The International journal of biochemistry - 1 Dec 1993
Manca L, Ferranti P, Barone F, Nitti G, Malorni A, Pucci P, Naitana S, Masala B
Abstract excerpt
1. The amino acid substitution which characterizes the haemoglobin I variant from sheep has been ascertained using a combination of Fast Atom Bombardment mass spectrometry and protein sequencing. 2. A Ser for Gly substitution at position 13 (10 of the A helix) was found in a polypeptide with the...
Topics
- Amino Acid Sequence
- Animals
- Globins
- Glycine
- Hemoglobins
- Hemoglobins, Abnormal
- Molecular Sequence Data
- Mutation
- Serine
- Sheep
- Spectrometry, Mass, Fast Atom Bombardment