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Article

A new beta-chain haemoglobin variant with increased oxygen affinity: Hb Roma [beta115(g17)Ala-->Val].

Biochimica et biophysica acta - 1 Mar 2010

Manconi Barbara, De Rosa Maria Cristina, Cappabianca Maria Pia, Olianas Alessandra, Carelli Alinovi Cristiana, Mastropietro Fabrizio, Ponzini Donatella, Amato Antonio, Pellegrini Mariagiuseppina

Abstract excerpt

BACKGROUND: Haemoglobin Roma [beta115(G17)Ala-->Val] is a new adult haemoglobin variant found in a patient presenting a mild hypochromia and microcytosis. We studied this previously uncharacterised variant in order to evaluate the effect on the structural and funcional properties of the Ala-->Val substitution at the alpha1beta1 interface. METHODS AND RESULTS: The variant chain was identified by direct DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19900509
DOI: 10.1016/j.bbagen.2009.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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