Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr.

doi:10.1002/(SICI)1096-9888(199708)32:8<880::AID-JMS547>3.0.CO;2-M

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr.

Journal of mass spectrometry : JMS - 1 Aug 1997

Déon C, Promé J C, Promé D, Francina A, Groff P, Kalmes G, Galactéros F, Wajcman H

Abstract excerpt

Mutation-induced amino acid exchanges occurring on the large T9 peptide of the alpha-chain of human hemoglobin (residues 62-90) are difficult to identify. Despite their high m/z value (around m/z 3000), collision-induced dissociation spectra of liquid secondary ion mass spectrometrically generated protonated alpha T9 peptides were performed successfully. In parallel electrospray mass spectrometry (MS) was used...

Topics

Amino Acid Sequence
Carboxypeptidases
Chromatography, High Pressure Liquid
Electrophoresis, Cellulose Acetate
Globins
Hemoglobin M
Hemoglobins, Abnormal
Humans
Mass Spectrometry
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Weight

Mutation

Peptides

Sequence Analysis

Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Trypsin

Source

Open in PubMed

Identifiers

PMID: 9269086
DOI: 10.1002/(SICI)1096-9888(199708)32:8<880::AID-JMS547>3.0.CO;2-M

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9269086-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr.PMID 9269086Read ↗

Electrospray tandem mass spectrometry of intact beta-chain hemoglobin variants.Semantic proximity Read ↗

[Location of amino acid substitutions in human hemoglobin. Mass spectrometric rapid analysis of tryptic peptides].Semantic proximity Read ↗

Identification of hemoglobin variants by top-down mass spectrometry using selected diagnostic product ions.Semantic proximity Read ↗

Short insertion in a hemoglobin chain: Hb Esch, an unstable alpha1 variant with duplication of the sequence Ala65-Leu-Thr-Asn68.Semantic proximity Read ↗

Cleavage by protease from Staphylococcus aureus V8: an improvement in the sequence analysis of human hemoglobin variants.Semantic proximity Read ↗

Novel hemoglobin (Hb Grey Lynn) substitution (alpha91Leu --> Phe) affects heme interactions and alpha1beta2 contacts.Semantic proximity Read ↗

Rapid identification of hemoglobin variants by electrospray ionization mass spectrometry.Semantic proximity Read ↗

Strategy for identification by mass spectrometry of a new human hemoglobin variant with two mutations in Cis in the beta-globin chain: Hb S-Clichy [beta6(A3)Glu-->Val; beta8(A5)Lys-->Thr].Semantic proximity Read ↗

Benign FGB (148Lys→Asn, and 448Arg→Lys), and novel causative γ211Tyr→His mutation distinguished by time of flight mass spectrometry in a family with hypofibrinogenaemia.Semantic proximity Read ↗

Bovine hemoglobin alpha-globin chain polymorphism: primary structure determination of two new genetic variants by mass spectrometry and amino acid sequencing.Semantic proximity Read ↗

Hb Santa Clara (beta 97His-->Asn), a human haemoglobin variant: functional characterization and structure modelling.Semantic proximity Read ↗

New alpha 2 globin chain variant with low oxygen affinity affecting the N-terminal residue and leading to N-acetylation [Hb Lyon-Bron alpha 1(NA1)Val --> Ac-Ala].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.