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Article

Hb City of Hope [beta 69(E13)Gly----Ser] in Italy: association of the gene with haplotype IX.

Hemoglobin - 1 Jan 1992

De Angioletti M, Maglione G, Ferranti P, de Bonis C, Lacerra G, Scarallo A, Pagano L, Fioretti G, Cutolo R, Malorni A

Abstract excerpt

Hb City of Hope [beta 69(E13)Gly----Ser] was detected by reversed phase high performance liquid chromatography in an asymptomatic carrier from Naples, Southern Italy. The amino acid substitution, identified by fast atom bombardment mass spectrometry, was due to a TGG----TGA substitution as assessed by DNA sequencing. Analysis of the chromosomal background indicates that the globin gene cluster containing the...

Topics

Base Sequence
Chromatography, High Pressure Liquid
Female
Globins
Haplotypes
Hemoglobins, Abnormal
Heterozygote
Humans
Italy
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymorphism, Restriction Fragment Length

Spectrometry, Mass, Fast Atom Bombardment

Source

Identifiers

PMID: 1353069
DOI: 10.3109/03630269209005673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1353069-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Hb City of Hope [beta 69(E13)Gly----Ser] in Italy: association of the gene with haplotype IX.PMID 1353069Read ↗

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Hb Marineo [beta70(E14)Ala-->Val]: a silent hemoglobin variant with a mutation within the heme pocket.Semantic proximity Read ↗

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The mutation associated with Hb Peterborough [beta111(G13)Val-->Phe] originated from Southern Italy.Semantic proximity Read ↗

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