Article
Inherited enhancement of hydroxyl radical generation and lipid peroxidation in the S strain rats results in DNA rearrangements, degenerative diseases, and premature aging.
Biochemical and biophysical research communications - 15 Mar 1994
Salganik R I, Solovyova N A, Dikalov S I, Grishaeva O N, Semenova L A, Popovsky A V
Abstract excerpt
Previously by selection and inbreeding of Wistar rats susceptible or resistant to the cataractogenic effect of galactose the S and R rat strains differing in the intensity of hexose transport into the animal cells were developed. High level of OH-radical generation and enhanced lipid peroxidation...
Topics
- Aging
- Animals
- Cataract
- DNA
- Female
- Fertility
- Genetic Predisposition to Disease
- Heart
- Hydroxyl Radical
- Intracellular Membranes
- Lipid Peroxidation
- Liver
- Longevity
- Lysosomes
- Male
- Mitochondria, Heart
- Mitochondria, Liver
- Myocardium