Article
Increased mRNA levels of Mn-SOD and catalase in embryos of diabetic rats from a malformation-resistant strain.
Diabetes - 1 Jan 2000
Cederberg J, Galli J, Luthman H, Eriksson U J
Abstract excerpt
Previous studies have suggested that reactive oxygen species (ROS) are mediators in the teratogenic process of diabetic pregnancy. In an animal model for diabetic pregnancy, offspring of the H rat strain show minor dysmorphogenesis when the mother is diabetic, whereas the offspring of diabetic rats of a sister strain, U, display major morphologic malformations. Earlier studies have shown that embryonic catalase...
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