Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High glucose level unmasks a genetic predisposition to enhanced extracellular matrix production in mesangial cells from the Milan normotensive strain.

Journal of the American Society of Nephrology : JASN - 1 Mar 1997

Pugliese G, Pricci F, Menè P, Romeo G, Nofroni I, Giannini S, Cresci B, Galli G, Rotella C M, Di Mario U, Pugliese F

Abstract excerpt

A growing body of evidence indicates that the individual genetic background plays a role in the pathogenesis of diabetic glomerular disease by either favoring or protecting against injury produced by hyperglycemia. Two genetically related rat strains, the Milan normotensive strain (MNS) and the M...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Cell Division
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension

Share to Rats, Inbred Strains

Share to Reference Values

Share to RNA, Messenger

Source

Identifiers

PMID: 9071709
DOI: 10.1681/ASN.V83406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9071709-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High glucose level unmasks a genetic predisposition to enhanced extracellular matrix production in mesangial cells from the Milan normotensive strain.PMID 9071709Read ↗

Glomerular barrier dysfunction in glomerulosclerosis- resistant Milan rats with experimental diabetes: the role of renal haemodynamics.Semantic proximity Read ↗

Naturally occurring perinatal growth restriction in mice programs cardiovascular and endocrine function in a sex- and strain-dependent manner.Semantic proximity Read ↗

Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype.Semantic proximity Read ↗

Rodent models of streptozotocin‐induced diabetic nephropathy (Methods in Renal Research)Semantic proximity Read ↗

High glucose-induced hypertrophy of mesangial cells requires p27(Kip1), an inhibitor of cyclin-dependent kinases.Semantic proximity Read ↗

High glucose induces a hypertrophic, senescent mesothelial cell phenotype after long in vivo exposure.Semantic proximity Read ↗

Glucose induces clonal selection and reversible dinucleotide repeat expansion in mesangial cells isolated from glomerulosclerosis-prone mice.Semantic proximity Read ↗

Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats.Semantic proximity Read ↗

Impact of genetic background on nephropathy in diabetic miceSemantic proximity Read ↗

Connective tissue growth factor (CTGF) expression modulates response to high glucose.Semantic proximity Read ↗

Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells.Semantic proximity Read ↗

Increased genetic susceptibility to renal damage in the stroke-prone spontaneously hypertensive rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.