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Article

Phenotypic knockout of CXCR4 by a novel recombinant protein TAT/54R/KDEL inhibits tumors metastasis.

Molecular cancer research : MCR - 1 Oct 2009

Ma Wei-Feng, Du Jun, Fu Liu-Peng, Fang Rui, Chen Hong-Yuan, Cai Shao-Hui

Abstract excerpt

The chemokine receptor, CXCR4, and its specific ligand, CXCL12, have been proven to regulate the directional trafficking and invasion of breast cancer cells to sites of metastases, and similar phenomena have also been identified in many malignant tumors that aberrantly overexpress CXCR4. Therefore, blocking the interaction between CXCR4 and CXCL12 is considered a possible approach to efficiently prevent cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Experimental

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Source

Identifiers

PMID: 19825996
DOI: 10.1158/1541-7786.MCR-09-0078

Genes

CXCR4
TAT
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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