Article
Transgenic mouse model of the mild dominant form of osteogenesis imperfecta.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Bonadio J, Saunders T L, Tsai E, Goldstein S A, Morris-Wiman J, Brinkley L, Dolan D F, Altschuler R A, Hawkins J E, Bateman J F
Abstract excerpt
Osteogenesis imperfecta type I is a mild, dominantly inherited, connective tissue disorder characterized by bone fragility. Mutations in type I collagen account for all known cases. In Mov-13 mice, integration of a murine retrovirus within the first intron of the alpha 1(I) collagen gene results...
Topics
- Animals
- Brain Stem
- Cell Line
- Collagen
- Collagen Type I, alpha 1 Chain
- Evoked Potentials, Auditory
- Female
- Genes, Dominant
- Humans
- Male
- Mice
- Mice, Transgenic
- Mutation
- Osteogenesis Imperfecta
- Reference Values