Article
Abnormal differentiation in MC3T3-E1 preosteoblasts expressing a dominant-negative type I collagen mutation.
Connective tissue research - 1 Jan 1996
Wenstrup R J, Witte D P, Florer J B
Abstract excerpt
To examine the effects that an organizing extracellular matrix might have on osteoblast precursors, we created MC3T3-E1 cell lines that stably incorporated a plasmid that expressed pro alpha 1 (I) collagen chains having a truncated triple helical domain. Cells that had incorporated the pro alpha...
Topics
- Alkaline Phosphatase
- Animals
- Ascorbic Acid
- Cell Differentiation
- Cell Division
- Cell Line
- Glycerophosphates
- Mice
- Mutation
- Osteoblasts
- Osteocalcin
- Procollagen
- Recombinant Fusion Proteins