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Article

The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer.

The Journal of biological chemistry - 5 Mar 1999

Guerrette S, Acharya S, Fishel R

Abstract excerpt

Germline mutations in two human mismatch repair (MMR) genes, hMSH2 and hMLH1, appear to account for approximately 70% of the common cancer susceptibility syndrome hereditary nonpolyposis colorectal cancer (HNPCC). Although the hMLH1 protein has been found to copurify with another MMR protein hPMS2 as a heterodimer, their function in MMR is unknown. In this study, we have identified the physical interaction...

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Identifiers

PMID: 10037723
DOI: 10.1074/jbc.274.10.6336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer.PMID 10037723Read ↗

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Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations.Semantic proximity Read ↗

Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch RepairSemantic proximity Read ↗

Functional analysis of MLH1 mutations linked to hereditary nonpolyposis colon cancer.Semantic proximity Read ↗

Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review.Semantic proximity Read ↗

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.Semantic proximity Read ↗

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Molecular basis of HNPCC: mutations of MMR genes.Semantic proximity Read ↗

Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms.Semantic proximity Read ↗

Risk of colorectal cancer for people with a mutation in both a MUTYH and a DNA mismatch repair gene.Semantic proximity Read ↗

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