Intergeneric complementation of a circadian rhythmicity defect: phylogenetic conservation of structure and function of the clock gene frequency.

doi:10.1002/j.1460-2075.1994.tb06507.x

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Article

Intergeneric complementation of a circadian rhythmicity defect: phylogenetic conservation of structure and function of the clock gene frequency.

The EMBO journal - 15 May 1994

Merrow M W, Dunlap J C

Abstract excerpt

The Neurospora crassa frequency locus encodes a 989 amino acid protein that is a central component, a state variable, of the circadian biological clock. We have determined the sequence of all or part of this protein and surrounding regulatory regions from additional fungi representing three genera and report that there is distinct, preferential conservation of the frequency open reading frame (ORF) as compared...

Topics

Amino Acid Sequence
Ascomycota
Base Sequence
Biological Clocks
Circadian Rhythm
Cloning, Molecular
Conserved Sequence
Fungal Proteins
Genes, Fungal
Genetic Complementation Test
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurospora crassa

Phenotype

Phylogeny

Sequence Analysis, DNA

Sequence Homology, Amino Acid

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 8194516
DOI: 10.1002/j.1460-2075.1994.tb06507.x
PMCID: PMC395087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8194516-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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