Reduced joining of DNA ends correlates with chromosomal instability in three melanoma cell lines.

Abstract excerpt

Chromosomal instability plays a pivotal role in multistep carcinogenesis by facilitating the acquisition of the multiple genetic alterations necessary for malignant transformation. In order to study the role of abnormal DNA repair in malignant melanoma, we measured the ability of cell lines from malignant melanoma and that of primary melanocytes to process 4 different kinds of DNA damage (pyrimidine dimers,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosome Aberrations
• Share to DNA Damage