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Article

Grade I, II and III Follicular Lymphomas Express Ig VH Genes with Different Patterns of Somatic Mutation.

Pathology oncology research : POR - 1 Oct 2020

Csernus Balázs, Timár Botond, Fülöp Zsolt, Matolcsy András

Abstract excerpt

Follicular lymphoma (FL) is an indolent, B-cell, non-Hodgkin's lymphoma with varying cytological appearance and clinical behavior. The genetic hallmark of FL is the t(14;18) translocation, and as a germinal center derived entity it is also characterized by somatic hypermutation of the immunoglobulin heavy chain (IgH) gene. In an attempt to correlate this molecular signature with the cytological grading of FL, we...

Topics

Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Lymphoma, Follicular
Mutation
Neoplasm Grading

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32705429
DOI: 10.1007/s12253-020-00843-x
PMCID: PMC7471144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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