An SRY-related sequence on the marsupial X chromosome: implications for the evolution of the mammalian testis-determining gene.

doi:10.1073/pnas.91.5.1927

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Article

An SRY-related sequence on the marsupial X chromosome: implications for the evolution of the mammalian testis-determining gene.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1994

Foster J W, Graves J A

Abstract excerpt

The SRY gene on the human, mouse, and marsupial Y chromosomes is the testis-determining gene that initiates male development in mammals. The SRY protein has a DNA-binding domain (high mobility group or HMG box) similar to those found in the high-mobility-group proteins. SRY is specific for the Y chromosome, but many autosomal genes have been identified that possess a similar HMG box region; those with the most...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
DNA
DNA-Binding Proteins
Dosage Compensation, Genetic
Female
High Mobility Group Proteins
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Marsupialia

Mice

Molecular Sequence Data

Nuclear Proteins

Restriction Mapping

SOXB1 Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 8127908
DOI: 10.1073/pnas.91.5.1927
PMCID: PMC43277

Genes

SRY
SOX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8127908-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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