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Article

Interactions between SRY and SOX genes in mammalian sex determination

6 Dec 1998

Abstract excerpt

The SRY gene on the mammalian Y chromosome undoubtedly acts to determine testis, but it is still quite unclear how. It was originally supposed that SRY acts directly to activate other genes in the testis-determining pathway. This paper presents an alternative hypothesis that SRY functions indirectly, by interacting with related genes SOX3 (from which SRY evolved) and SOX9 (which appears to be intimately involved...

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Identifiers

PMID: 9631654
DOI: 10.1002/(sici)1521-1878(199803)20:3<264::aid-bies10>3.0.co;2-1

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