Article
Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-determination pathway.
American journal of human genetics - 1 Jan 2001
Patel M, Dorman K S, Zhang Y H, Huang B L, Arnold A P, Sinsheimer J S, Vilain E, McCabe E R
Abstract excerpt
The molecular evolution of DAX1, SRY, and SOX9, genes involved in mammalian sex determination, was examined in six primate species. DAX1 and SRY have been added to the X and Y chromosomes, respectively, during mammalian evolution, whereas SOX9 remains autosomal. We determined the genomic sequences of DAX1, SRY, and SOX9 in all six species, and calculated K(a), the number of nonsynonymous substitutions per...
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