Article
Apolipoprotein B and a second major gene locus contribute to phenotypic variation of spontaneous hypercholesterolemia in pigs.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Mar 1994
Aiello R J, Nevin D N, Ebert D L, Uelmen P J, Kaiser M E, MacCluer J W, Blangero J, Dyer T D, Attie A D
Abstract excerpt
The Lpb5 apolipoprotein B (apoB) allele occurs in pigs with spontaneous hypercholesterolemia. Low-density lipoprotein (LDL) from these pigs binds to the LDL receptor with a lower affinity and is cleared from the circulation more slowly than control pig LDL. However, the severity of hypercholester...
Topics
- Animals
- Apolipoproteins B
- Chromosome Mapping
- Hypercholesterolemia
- Lipoproteins, LDL
- Metabolic Clearance Rate
- Pedigree
- Phenotype
- Receptors, LDL
- Swine
- Swine Diseases