Article
Porcine von Willebrand disease and atherosclerosis. Influence of polymorphism in apolipoprotein B100 genotype.
The American journal of pathology - 1 Feb 1992
Nichols T C, Bellinger D A, Davis K E, Koch G G, Reddick R L, Read M S, Rapacz J, Hasler-Rapacz J, Brinkhous K M, Griggs T R
Abstract excerpt
The relationship of apolipoprotein-B genotype (Lpb) to diet-induced hypercholesterolemia and atherosclerosis was studied in von Willebrand disease (vWD) and normal pigs. Von Willebrand and normal pigs developed comparable levels of hypercholesterolemia (respectively, 757.9 +/- 49.4 versus 772.8 +/- 47.9 mg/dl, P = 0.95). Pigs with Lpb1/5 and Lpb5/8 genotypes, however, developed significantly higher serum...
Topics
- Animals
- Aortic Diseases
- Apolipoprotein B-100
- Apolipoproteins B
- Arteriosclerosis
- Cholesterol
- Coronary Artery Disease
- Diet, Atherogenic
- Genotype
- Male
- Polymorphism, Genetic