Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants in ABCA1 promoter affect transcription activity and plasma HDL level in pigs.

Gene - 25 Jan 2015

Dang Xiao-yong, Chu Wei-wei, Shi Heng-chuan, Yu Shi-gang, Han Hai-yin, Gu Shu-Hua, Chen Jie

Abstract excerpt

Excess accumulation of cholesterol in plasma may result in coronary artery disease. Numerous studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) mediates the efflux of cholesterol and phospholipids to apolipoproteins, a process necessary for plasma high density lipoprotein (HDL) formation. Higher plasma levels of HDL are associated with lower risk for cardiovascular disease. Studies of human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter 1
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homozygote

Share to Lipoproteins, HDL

Share to Mutagenesis, Site-Directed

Share to Plasmids

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 25445391
DOI: 10.1016/j.gene.2014.11.041

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in ABCA1 promoter affect transcription activity and plasma HDL level in pigs.PMID 25445391Read ↗

Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels.Semantic proximity Read ↗

A novel haplotype in ABCA1 gene effects plasma HDL-C concentration.Semantic proximity Read ↗

Genomic Variants and Multilevel Regulation of ABCA1, ABCG1, and SCARB1 Expression in AtherogenesisSemantic proximity Read ↗

Nucleotide sequence and association analysis of pig apolipoprotein-B and LDL-receptor genes.Semantic proximity Read ↗

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.Semantic proximity Read ↗

Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks.Semantic proximity Read ↗

Genetic disorders associated with ATP binding cassette cholesterol transporters.Semantic proximity Read ↗

Functional and association studies of the cholesteryl ester transfer protein (CETP) gene in a Wannan Black pig model.Semantic proximity Read ↗

A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese population.Semantic proximity Read ↗

Genotypic variation in ATP-binding cassette transporter-1 (ABCA1) as contributors to the high and low high-density lipoprotein-cholesterol (HDL-C) phenotype.Semantic proximity Read ↗

A functional variant in the porcine APOA2 promoter alters hepatic gene expression via RORα.Semantic proximity Read ↗

Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.