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Article

Overproduction of a buoyant low density lipoprotein subspecies in spontaneously hypercholesterolemic mutant pigs.

Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000

Checovich W J, Aiello R J, Attie A D

Abstract excerpt

We previously described the hypercholesterolemia of pigs with defined apolipoprotein B (apo B) alleles associated with reduced binding of low density lipoprotein (LDL) to its receptor in vitro and slow clearance from the circulation in vivo. The increased plasma LDL in the hypercholesterolemic pigs was confined to a buoyant LDL subspecies. Because of this qualitative change in the LDL subspecies profile, we...

Topics

Animals
Apolipoproteins B
Hypercholesterolemia
Lipoproteins, LDL
Phenotype
Swine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1998653
DOI: 10.1161/01.atv.11.2.351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1998653-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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