Article
Retinoic acid negatively regulates beta 4 integrin expression and suppresses the malignant phenotype in a Lewis lung carcinoma cell line.
Clinical & experimental metastasis - 1 Jan 1994
Gaetano C, Melchiori A, Albini A, Benelli R, Falcioni R, Modesti A, Modica A, Scarpa S, Sacchi A
Abstract excerpt
Retinoic acid (RA) is a potent inhibitor of the malignant phenotype and of tumour cell growth. We observed that in vitro RA treatment of a highly metastatic lung carcinoma cell line (C87) induced a marked reduction in the amount of the beta 4 integrin subunit. The downregulation of this adhesion...
Topics
- Animals
- Cell Differentiation
- DNA
- Integrins
- Lung Neoplasms
- Mice
- Mice, Inbred C57BL
- Neoplasms, Experimental
- Phenotype
- Tretinoin
- Tumor Cells, Cultured