Article
Effect of v-rasH on sensitivity of NCI-H82 human small cell lung cancer cells to cisplatin, etoposide, and camptothecin.
Biochemical pharmacology - 22 Dec 1995
Kaufmann S H, Kalemkerian G P, Jasti R, Mabry M
Abstract excerpt
Expression of v-ras(H) in NCI-H82 human small cell lung cancer (SCLC) cells results in a line (NCI-H82ras(H)) with a non-small cell phenotype (Mabry et al., Proc Natl Acad Sci USA 85: 6523-6527, 1988). This v-ras(H) -associated phenotypic change is prevented by treatment with trans-retinoic acid...
Topics
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Camptothecin
- Carcinoma, Small Cell
- Cell Survival
- Cisplatin
- Drug Resistance
- Etoposide
- Genes, ras
- Humans
- Lung Neoplasms
- Metallothionein
- Phenotype
- RNA, Messenger
- RNA, Transfer
- Sulfhydryl Compounds
- Transfection
- Tumor Cells, Cultured