Raf-1 Causes Growth Suppression and Alteration of Neuroendocrine Markers in DMS53 Human Small-Cell Lung Cancer Cells

Abstract excerpt

Ras mutations are common in lung adenocarcinomas and squamous-cell cancers, which are non-small-cell lung cancers (NSCLCs). However, small-cell lung cancers (SCLCs) rarely have ras mutations, suggesting that ras activation may not confer a growth advantage in these cells. In one SCLC cell line DMS53, activated ras expression induced increased neuroendocrine differentiation and decreased cell proliferation. We...

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