Article
Integrated clinical and basic studies related to circumventing non-small cell lung cancer drug resistance.
Lung cancer (Amsterdam, Netherlands) - 1 Mar 1994
Mulshine J L, Johnson B E, Gazdar A F, Shaw G L, Kramer B S, Mitsudomi T, Minna J D, Pass H, Phelps R, Ghosh B
Abstract excerpt
Consideration of a range of clinical and basic studies conducted at the National Cancer Institute which explore the nature of the tumor biology of lung identify the limitations of using chemotherapy for the treatment of advanced lung cancer. No single mechanistic explanation for lung cancer's chemoresistance is apparent, although considerable information about the biology of lung cancer and some of its clinical...
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