Article
Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi.
Molecular biology and evolution - 1 Jan 1994
Caporale D A, Kocher T D
Abstract excerpt
Borrelia burgdorferi is a spirochete pathogen transmitted among warm-blooded hosts by ixodid ticks. Frequency-dependent selection for variant outer-surface proteins might be expected to arise in this species, since rare variants are more likely to avoid immune surveillance in previously infected hosts. We sequenced the OspA and OspB genes of nine North American strains and compared them with nine strains...
Topics
- Animals
- Antigens, Bacterial
- Antigens, Surface
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Base Sequence
- Borrelia burgdorferi Group
- DNA Primers
- DNA, Bacterial
- Genes, Bacterial
- Genetic Variation