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The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans.

The American journal of tropical medicine and hygiene - 1 May 2008

Dykhuizen Daniel E, Brisson Dustin, Sandigursky Sabina, Wormser Gary P, Nowakowski John, Nadelman Robert B, Schwartz Ira

Abstract excerpt

Lineages of Borrelia burgdorferi, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (ospC) locus. The lineages marked by ospC genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, I, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the...

Topics

Animals
Blood
Borrelia burgdorferi
Cerebrospinal Fluid
Genotype
Humans
Ixodes
Lyme Disease
Mammals
Species Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18458317
PMCID: PMC2387051

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