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Article

Pervasive recombination and sympatric genome diversification driven by frequency-dependent selection in Borrelia burgdorferi, the Lyme disease bacterium.

Genetics - 1 Nov 2011

Haven James, Vargas Levy C, Mongodin Emmanuel F, Xue Vincent, Hernandez Yozen, Pagan Pedro, Fraser-Liggett Claire M, Schutzer Steven E, Luft Benjamin J, Casjens Sherwood R, Qiu Wei-Gang

Abstract excerpt

How genomic diversity within bacterial populations originates and is maintained in the presence of frequent recombination is a central problem in understanding bacterial evolution. Natural populations of Borrelia burgdorferi, the bacterial agent of Lyme disease, consist of diverse genomic groups co-infecting single individual vertebrate hosts and tick vectors. To understand mechanisms of sympatric genome...

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Identifiers

PMID: 21890743
DOI: 10.1534/genetics.111.130773
PMCID: PMC3213364

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