Article
Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis.
Hepatology (Baltimore, Md.) - 1 Mar 1994
Doherty D G, Donaldson P T, Underhill J A, Farrant J M, Duthie A, Mieli-Vergani G, McFarlane I G, Johnson P J, Eddleston A L, Mowat A P
Abstract excerpt
Susceptibility to autoimmune hepatitis in white patients is associated with the human leukocyte antigen class II antigens DR3 and DR4. To analyze the molecular basis of these associations, we used oligonucleotide probes to determine the DRB, DQA and DQB hypervariable nucleotide sequences in 119 p...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Amino Acid Sequence
- Autoimmune Diseases
- Child
- Child, Preschool
- Female
- Genes, MHC Class II
- Genetic Variation
- Hepatitis
- Histocompatibility Antigens Class II
- Humans
- Male
- Middle Aged
- Molecular Conformation