Article
Amino acid substitutions at position 38 of the DR beta polypeptide confer susceptibility to and protection from primary sclerosing cholangitis.
Hepatology (Baltimore, Md.) - 1 Aug 1992
Farrant J M, Doherty D G, Donaldson P T, Vaughan R W, Hayllar K M, Welsh K I, Eddleston A L, Williams R
Abstract excerpt
Previous studies based on serological HLA phenotyping have implicated genes in the HLA class II region in susceptibility to and protection from primary sclerosing cholangitis. In a recent report, the HLA DRw52a antigen was present in all 29 patients who had been referred for liver transplantation...
Topics
- Alleles
- Base Sequence
- Cholangitis, Sclerosing
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Humans
- Molecular Sequence Data
- Peptides
- Structure-Activity Relationship