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Article

Susceptibility to type 1 autoimmune hepatitis is associated with shared amino acid sequences at positions 70-74 of the HLA-DRB1 molecule.

Journal of hepatology - 1 Jan 2008

Lim Young-Suk, Oh Heung-Bum, Choi Sung-Eun, Kwon Oh-Joong, Heo Yong-Seok, Lee Han Chu, Suh Dong Jin

Abstract excerpt

BACKGROUND/AIMS: The risk of developing autoimmune hepatitis (AIH) has been suggested to be associated with the presence of HLA-DRB1 alleles encoding the 'shared epitope' at amino acid positions 67-72 in the third hypervariable region (HVR3) of DRbeta. We aimed to identify the specific HLA alleles that are susceptible to type 1 AIH in Koreans, and to validate the shared epitope hypothesis in this single ethnic...

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Identifiers

PMID: 18022727
DOI: 10.1016/j.jhep.2007.08.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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