Article
Genetic bases of autoimmune hepatitis.
Digestive diseases and sciences - 1 Oct 2002
Czaja Albert J, Doherty Derek G, Donaldson Peter T
Abstract excerpt
Our goal was to review the hypotheses in evolution that promise to elucidate the genetic bases of autoimmune hepatitis. DRB1*0301 and DRB1*0401 are the principal risk factors in Britain and the United States. Other susceptibility alleles in different ethnic groups commonly share the same or a similar motif at the critical DRbeta71 position of the HLA class II molecule. Disease severity may be determined by the...
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