Structural Domains of the Herpes Simplex Virus 1 gD Protein That Restrict Human Immunodeficiency Virus Particle Infectivity

Abstract excerpt

Previously, we showed that unlike the HSV-1, the presence of the gD glycoprotein in virus producer cells but not gB potently restricted HIV-1 particle infectivity. To better understand the relationship between cell surface expression, virus incorporation and restriction of HIV-1, we analyzed a series of deletion mutants and chimeric proteins in which domains of gD and gB were swapped. Our results indicate that:...

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