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Article

Mutations in herpes simplex virus glycoprotein D distinguish entry of free virus from cell-cell spread.

Journal of virology - 1 Dec 2000

Rauch D A, Rodriguez N, Roller R J

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) is an essential component of the entry apparatus that is responsible for viral penetration and subsequent cell-cell spread. To test the hypothesis that gD may serve distinguishable functions in entry of free virus and cell-cell spread, mutants were selected for growth on U(S)11cl19.3 cells, which are resistant to both processes due to the lack of a...

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Identifiers

PMID: 11090139
DOI: 10.1128/jvi.74.24.11437-11446.2000
PMCID: PMC112422

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