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Article

Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis.

Development (Cambridge, England) - 1 Nov 2004

Jain Sanjay, Naughton Cathy K, Yang Mao, Strickland Amy, Vij Kiran, Encinas Mario, Golden Judy, Gupta Akshay, Heuckeroth Robert, Johnson Eugene M, Milbrandt Jeffrey

Abstract excerpt

The Ret receptor tyrosine kinase mediates physiological signals of glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) and is essential for postnatal survival in mice. It is implicated in a number of human diseases and developmental abnormalities. Here, we describe our analyses of mice expressing a Ret mutant (RetDN) with diminished kinase activity that inhibits wild-type Ret activity,...

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Share to Glial Cell Line-Derived Neurotrophic Factor Receptors
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15469971
DOI: 10.1242/dev.01421

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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